Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000457)
Formula Reactant Bromfenac indolinone Product Bromfenac metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000456 Bromfenac glucuronide intemediate Bromfenac indolinone Unclear Bromfenac [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000458 Bromfenac indolinone Bromfenac metabolite M3 Unclear Bromfenac [1], [2]
MR000459 Bromfenac indolinone Bromfenac metabolite M4 Unclear Bromfenac [1], [2]
MR000460 Bromfenac indolinone Bromfenac metabolite M5 Unclear Bromfenac [1], [2]
References
1 Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257.
2 Metabolic disposition of 14C-bromfenac in healthy male volunteers J Clin Pharmacol. 1998 Aug;38(8):744-52. doi: 10.1002/j.1552-4604.1998.tb04815.x.

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