Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001487)
DM Name	Bromfenac metabolite M3

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Bromfenac indolinone	Unclear - Unclear	Bromfenac	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Bromfenac		DR1765	Approved		Cataract

References
1	Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257.
2	Metabolic disposition of 14C-bromfenac in healthy male volunteers J Clin Pharmacol. 1998 Aug;38(8):744-52. doi: 10.1002/j.1552-4604.1998.tb04815.x.

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