Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000544)
Formula
CYP1A2 ...
SVG example
8-Hydroxylation
Reactant Caffeine Product 1,3,7-Trimethyluric acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - 8-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000543 Caffeine Paraxanthine Oxidation - Demethylation Caffeine [1], [2]
MR000545 Caffeine Theobromine Oxidation - 1-N-Demethylation Caffeine [3], [2]
MR000546 Caffeine Theophylline Oxidation - 7-N-Demethylation Caffeine [3], [2]
References
1 Pharmacokinetic analysis and comparison of caffeine administered rapidly or slowly in coffee chilled or hot versus chilled energy drink in healthy young adults Clin Toxicol (Phila). 2016;54(4):308-12. doi: 10.3109/15563650.2016.1146740.
2 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
3 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.

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