Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002840)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Dapagliflozin Product Dapagliflozin BMS-639432
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002838 Dapagliflozin Dapagliflozin 3-O-glucuronide metabolite Conjugation - Glucuronidation Dapagliflozin [1]
MR002839 Dapagliflozin Dapagliflozin BMS-511926 Oxidation - O-Deethylation Dapagliflozin [2]
References
1 Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus
2 In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans Drug Metab Dispos. 2010 Mar;38(3):405-14. doi: 10.1124/dmd.109.029165.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.