Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003935)
Formula
SVG example
Reactant SPD Product AcSPD N1-acetylspermidine
Reactant Info Product Info
Metabolic Enzyme Putrescine acetyltransferase (SSAT1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003936 KM-1406 SPD Oxidation - Oxidationn KM-1406 [1]
MR007654 Putrescine Spermidine Other reaction - N-Decarboxylation Putrescine [2]
MR003934 AcSPM SPD Unclear KM-1406 [1]
MR003067 Putrescine Spermidine Unclear Agmatine [3], [4], [5]
MR012735 Putrescine Spermidine Unclear - Unclear Arginine [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003071 Spermidine MTA Unclear Agmatine [3]
MR003070 Spermidine N1-AcSpd Unclear Agmatine [3]
MR003068 Spermidine Spermine Unclear Agmatine [3], [4], [5]
MR012736 Spermidine Spermine Unclear - Unclear Arginine [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000579 CCG-205124 N-Acetylspermidine Unclear CCG-205124 [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000577 N-Acetylspermidine Putrescine Unclear CCG-205124 [7]
References
1 Spermine metabolism and anticancer therapy
2 Human aldehyde dehydrogenase: metabolism of putrescine and histamine
3 Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine Amino Acids. 2004 Feb;26(1):3-8. doi: 10.1007/s00726-003-0030-z.
4 Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought. BMC Genomics. 2022 Oct 30;23(1):734. doi: 10.1186/s12864-022-08946-2.
5 Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body. Biomolecules. 2022 Mar 25;12(4):501. doi: 10.3390/biom12040501.
6 Arginine Metabolism Revisited
7 The Association between Spermidine/Spermine N(1)-Acetyltransferase (SSAT) and Human Malignancies Int J Mol Sci. 2022 May 25;23(11):5926. doi: 10.3390/ijms23115926.

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