Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004650)
Formula
PTGS1 ...
SVG example
4-hydroxylation
Reactant Ifosfamide Product 4-Hydroxyifosfamide
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - 4-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004662 Ifosfamide 3-Dechloroethylifosfamide Unclear Ifosfamide [1], [2]
MR004660 Ifosfamide Chloroacetaldehyde Unclear Ifosfamide [2], [3]
MR004663 Ifosfamide Dechloroethylifosfamide Unclear Ifosfamide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004658 4-Hydroxyifosfamide 4-Ketoifosfamide Unclear Ifosfamide [2]
MR004659 4-Hydroxyifosfamide 4-Thioifosfamide Conjugation - Glutathione conjugation Ifosfamide [4]
MR004651 4-Hydroxyifosfamide Aldoifosfamide Unclear Ifosfamide [4]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 The KEGG resource for deciphering the genome
3 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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