Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004716)
Formula
SVG example
Hydrolyzationn
Reactant Metoprolol tartrate Product Alpha-Hydroxymetoprolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004723 Metoprolol tartrate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol tartrate [1]
MR004724 Metoprolol tartrate H104/83 Unclear Metoprolol tartrate [2]
MR004720 Metoprolol tartrate H105/22 Unclear Metoprolol tartrate [2]
MR004722 Metoprolol tartrate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol tartrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004707 Metoprolol succinate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol succinate [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004708 Alpha-Hydroxymetoprolol H119/72 Unclear Metoprolol succinate [2]
MR004717 Alpha-Hydroxymetoprolol H119/72 Unclear Metoprolol tartrate [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of metoprolol in the rat in vitro and in vivo
3 DrugBank(Pharmacology-Metabolism):Metoprolol succinate

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