Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004722)
Formula
CYP2D6 ...
SVG example
O-dealkylation
Reactant Metoprolol tartrate Product O-Demethylmetoprolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004716 Metoprolol tartrate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol tartrate [1]
MR004723 Metoprolol tartrate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol tartrate [2]
MR004724 Metoprolol tartrate H104/83 Unclear Metoprolol tartrate [1]
MR004720 Metoprolol tartrate H105/22 Unclear Metoprolol tartrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004713 Metoprolol succinate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol succinate [2]
References
1 Metabolism of metoprolol in the rat in vitro and in vivo
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

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