Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004994)
Formula Reactant Timolol maleate Product M1 metabolite, timolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004997 Timolol maleate Timolol maleate Metabolite M2 Unclear Timolol maleate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004996 M1 metabolite, timolol Timolol maleate Metabolite M3 Unclear Timolol maleate [1]
MR004995 M1 metabolite, timolol Timolol maleate Metabolite M4 Unclear Timolol maleate [1]
References
1 Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.

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