| General Information of This Metabolic Reaction (MR) (ID:
MR004997) |
| Formula |
|
| Reactant |
Timolol maleate |
Product |
Timolol maleate Metabolite M2 |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 1A2 (CYP1A2)
|
DME Info
|
|
Cytochrome P450 2C9 (CYP2C9)
|
DME Info
|
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Cytochrome P450 2D6 (CYP2D6)
|
DME Info
|
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME Info
|
|
Cytochrome P450 2A6 (CYP2A6)
|
DME Info
|
|
Cytochrome P450 2C8 (CYP2C8)
|
DME Info
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Reactant of This MR |
|
Other MR(s) That Metabolize The Reactant of This MR
|
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|
| References |
| 1 |
Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.
|
| 2 |
Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303.
|
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