General Information of This Metabolic Reaction (MR) (ID: MR004997)
Formula
CYP1A2 ...
SVG example
Reactant Timolol maleate Product Timolol maleate Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004994 Timolol maleate M1 metabolite, timolol Oxidation - Hydrolyzationn Timolol maleate [1], [2]
References
1 Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.
2 Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303.

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