Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004650)
DM Name	Timolol maleate Metabolite M4
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	M1 metabolite, timolol	Unclear - Unclear	Timolol maleate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Timolol maleate		DR1595	Approved		Essential hypertension

References
1	Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.

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