General Information of Drug Metabolite (DM) (ID: DM004650)
DM Name
Timolol maleate Metabolite M4
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Timolol maleate [1]
Cytochrome P450 2A6 (CYP2A6) DME0005 Unclear - Unclear Timolol maleate [1]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear Timolol maleate [1]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Timolol maleate [1]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Timolol maleate [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Timolol maleate [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Timolol maleate [1]
Full List of Drug(s) That Produce This DM By Metabolism
Timolol maleate DR1595 Approved Essential hypertension
References
1 Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.

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