Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005698)
Formula
CYP3A4 ...
SVG example
Methyl-hydroxylation; oxidation
Reactant Zolpidem tartrate Product Methoxyzolpidem derivative (M4)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Methyl-hydroxylation; oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005700 Zolpidem tartrate 7-Hydroxy zolpidem Oxidation - Aliphatic hydroxylation Zolpidem tartrate [1]
MR005701 Zolpidem tartrate 8-Hydroxy zolpidem Oxidation - Aliphatic hydroxylation Zolpidem tartrate [1]
MR005702 Zolpidem tartrate Methoxyzolpidem Oxidation - Aliphatic hydroxylation Zolpidem tartrate [2], [3]
MR005696 Zolpidem tartrate Methoxyzolpidem derivative (M3) Oxidation - Methyl-hydroxylation Zolpidem tartrate [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005699 Methoxyzolpidem derivative (M4) Zolpidem carboxylic acid derivative (M2) Oxidation - Oxidationn Zolpidem tartrate [2], [3]
References
1 Qualitative analysis of 7- and 8-hydroxyzolpidem and discovery of novel zolpidem metabolites in postmortem urine using liquid chromatography-tandem mass spectrometry
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Zolpidem urine excretion profiles and cross-reactivity with ELISA(?) kits in subjects using Zolpidem or Ambien(?) CR as a prescription sleep aid

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