Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005702)
Formula
CYP2C9 ...
SVG example
Aliphatic hydroxylation
Reactant Zolpidem tartrate Product Methoxyzolpidem
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005700 Zolpidem tartrate 7-Hydroxy zolpidem Oxidation - Aliphatic hydroxylation Zolpidem tartrate [1]
MR005701 Zolpidem tartrate 8-Hydroxy zolpidem Oxidation - Aliphatic hydroxylation Zolpidem tartrate [1]
MR005696 Zolpidem tartrate Methoxyzolpidem derivative (M3) Oxidation - Methyl-hydroxylation Zolpidem tartrate [2], [3]
MR005698 Zolpidem tartrate Methoxyzolpidem derivative (M4) Oxidation - Methyl-hydroxylation; oxidation Zolpidem tartrate [2], [3]
References
1 Qualitative analysis of 7- and 8-hydroxyzolpidem and discovery of novel zolpidem metabolites in postmortem urine using liquid chromatography-tandem mass spectrometry
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Zolpidem urine excretion profiles and cross-reactivity with ELISA(?) kits in subjects using Zolpidem or Ambien(?) CR as a prescription sleep aid

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