Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006906)
Formula
CYP1A1 ...
SVG example
Hydrolyzationn
Reactant Lorcaserin Product N-hydroxylorcaserin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Dimethylaniline oxidase 1 (FMO1) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006907 Lorcaserin 1-Hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
MR006908 Lorcaserin 5-Hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
MR006909 Lorcaserin 7-Hydroxylorcaserin Oxidation - Hydrolyzationn Lorcaserin [1]
MR006911 Lorcaserin Lorcaserin metabolite M5 Unclear Lorcaserin [2]
MR006910 Lorcaserin Lorcaserin sulfamate Unclear Lorcaserin [2]
References
1 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71.
2 DrugBank(Pharmacology-Metabolism):Lorcaserin

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