Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006925)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Loxapine succinate Product Loxapine N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Flavin-containing monooxygenase (FMO) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 1B1 (CYP1B1) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006926 Loxapine succinate 7-Hydroxyloxapine Oxidation - Oxidationn Loxapine succinate [1]
MR006928 Loxapine succinate 8-Hydroxyloxapine Oxidation - Oxidationn Loxapine succinate [1]
MR006927 Loxapine succinate Amoxapine Oxidation - Oxidationn Loxapine succinate [1]
References
1 In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407.

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