Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007163)
Formula
CYP3A4 ...
SVG example
1-N-oxidation
Reactant Etoricoxib Product Etoricoxib 1'-N'-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - 1-N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007165 Etoricoxib 6-Hydroxymethyletoricoxib Other reaction - 6-methylhydroxylation Etoricoxib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007164 Etoricoxib 1'-N'-oxide 6-Hydroxymethyletoricoxib-1'-N'-oxide Other reaction - 6-methylhydroxylation Etoricoxib [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers

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