Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007164)
Formula Reactant Etoricoxib 1'-N'-oxide Product 6-Hydroxymethyletoricoxib-1'-N'-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Other reaction - 6-methylhydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007163 Etoricoxib Etoricoxib 1'-N'-oxide Oxidation - 1-N-oxidation Etoricoxib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007168 6-Hydroxymethyletoricoxib 6-Hydroxymethyletoricoxib-1'-N'-oxide Oxidation - 1-N-oxidation Etoricoxib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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