Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009369)
Formula
CYP2D6 ...
SVG example
N-oxidation
Reactant AZD0328 Product AZD0328 Metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Dimethylaniline oxidase 1 (FMO1) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009368 AZD0328 AZD0328 Metabolite M2 Conjugation - N-methylation AZD0328 [1]
MR009365 AZD0328 AZD0328 Metabolite M4 Oxidation - Hydroxylation AZD0328 [1]
MR009367 AZD0328 AZD0328 Metabolite M5 Oxidation - Hydroxylation AZD0328 [1]
References
1 In vitro metabolism of 7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite

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