Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009942)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Cyclophosphamide Product 4-Hydroxycyclophosphamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009948 Cyclophosphamide Dechloroethyl cyclophosphamide Unclear - Unclear Cyclophosphamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [2], [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009947 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear - Unclear Cyclophosphamide [1]
MR012906 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear Cyclobenzaprine [3]
MR009943 4-Hydroxycyclophosphamide Aldophosphamide Unclear - Unclear Cyclophosphamide [1]
MR012898 4-Hydroxycyclophosphamide Aldophosphamide Unclear Cyclobenzaprine [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 The KEGG resource for deciphering the genome
3 U. S. FDA Label -Cyclobenzaprine

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