Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011144)
Formula
CYP3A4 ...
SVG example
N-dealkylation
Reactant BMS-201038 Product Lomitapide Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011145 BMS-201038 Lomitapide Metabolite M3 Oxidation - Oxidation BMS-201038 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006893 Lomitapide mesylate Lomitapide metabolite M1 Other reaction - Cleavage Lomitapide mesylate [2]
References
1 LABEL: JUXTAPID- lomitapide mesylate capsule
2 Evaluation of the effects of the weak CYP3A inhibitors atorvastatin and ethinyl estradiol/norgestimate on lomitapide pharmacokinetics in healthy subjects. J Clin Pharmacol. 2016 Jan;56(1):47-55.

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