Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012007)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Imatinib Product N-desmethyl-imatinib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012008 Imatinib Other imatinib metabolites Unclear - Unclear Imatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004669 Imatinib mesylate N-Desmethylimatinib Oxidation - N-demethylation Imatinib mesylate [2], [3], [4]
References
1 Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes
4 In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1

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