Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004669)
Formula
CYP2C9 ...
SVG example
N-demethylation
Reactant Imatinib mesylate Product N-Desmethylimatinib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 4F2 (CYP4F2) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004670 Imatinib mesylate AFN911 Oxidation - Benzyl hydroxylation Imatinib mesylate [1]
MR004677 Imatinib mesylate APG049 imatinib Oxidation - Oxidationn Imatinib mesylate [2]
MR004676 Imatinib mesylate APG050 imatinib Oxidation - Oxidationn Imatinib mesylate [2]
MR004667 Imatinib mesylate Deaminated imatinib Multi-steps Reaction - Oxidationn deamination; carboxylation Imatinib mesylate [2]
MR004675 Imatinib mesylate M28.8 imatinib Oxidation - Oxidationn Imatinib mesylate [2]
MR004674 Imatinib mesylate M29.6 imatinib Oxidation - Oxidationn Imatinib mesylate [2]
MR004673 Imatinib mesylate M7 N-oxidation imatinib Oxidation - N-oxidation Imatinib mesylate [1]
MR004671 Imatinib mesylate Piperidine N-oxide imatinib Oxidation - N-4 oxidation Imatinib mesylate [1]
MR004672 Imatinib mesylate Pyridine N-oxide imatinib Oxidation - N-oxidation Imatinib mesylate [1]
MR004668 Imatinib mesylate M42.2 imatinib Multi-steps Reaction - Oxidationn deamination; carboxylation Imatinib mesylate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012007 Imatinib N-desmethyl-imatinib Unclear - Unclear Imatinib [3]
References
1 In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1
2 Metabolism and disposition of imatinib mesylate in healthy volunteers
3 Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism

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