Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00292)
Xenobiotics Name
Doxorubicin hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
443939
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Acid phosphatase-like protein 1 (ACP6) DME Info Homo sapiens [1]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [1]
Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Succinic semialdehyde reductase (AKR7A2) DME Info Homo sapiens [2]
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 7 (ALDH7) DME Info Homo sapiens [1], [3]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [1]
Copper amine oxidase (AOC3) DME Info Homo sapiens [1]
Aquaporin adipose (AQP7) DME Info Homo sapiens [1]
Arylsulfatase B (ARSB) DME Info Homo sapiens [1]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [1]
Bleomycin hydrolase (BLMH) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [1]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [1]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [1]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1]
Dimethylaniline oxidase 2 (FMO2) DME Info Homo sapiens [1]
Folylpolyglutamate synthase (FPGS) DME Info Homo sapiens [1]
Friedreich ataxia protein (FXN) DME Info Homo sapiens [1]
Glutamyl-tRNA(Gln) amidotransferase B (GATB) DME Info Homo sapiens [1]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [1]
Gamma-glutamyltranspeptidase 5 (GGT5) DME Info Homo sapiens [1]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
Beta-glucuronidase (GUSB) DME Info Homo sapiens [1]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [1]
Ketoacyl-CoA reductase (HSD17B12) DME Info Homo sapiens [1]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [1]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
Neprilysin (MME) DME Info Homo sapiens [4]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Methionine-R-sulfoxide reductase B2 (MSRB2) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [1]
Methionine synthase reductase (MTRR) DME Info Homo sapiens [1]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [1]
Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [1]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [1]
Phosphorylcholine transferase A (PCYT1A) DME Info Homo sapiens [1]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [1]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [1]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [1]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [1]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [1]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [1]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Xylosyl phosphatase (PXYLP1) DME Info Homo sapiens [1]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [1]
Steroid 5-alpha-reductase 3 (SRD5A3) DME Info Homo sapiens [1]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [1]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [1]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [6]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [7]
Uracil phosphoribosyltransferase (UPRT) DME Info Homo sapiens [1]
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME Info Homo sapiens [1]
Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1], [3]
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [8]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [8]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [9]
NADPH-dependent carbonyl reductase 1 (CBR1) DME Info Homo sapiens [10]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [11]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [12]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [3]
Galactose kinase (GALK1) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [13]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [14]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [1]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [1]
Glutamine-dependent NAD(+) synthetase (NADSYN1) DME Info Homo sapiens [3]
Alpha-N-acetylglucosaminidase (NAG) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [15], [16]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [9]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [1]
Transglutaminase H (TGM2) DME Info Homo sapiens [1], [17]
References
1 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
2 Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes. Toxicol Lett. 2019 Jun 1;307:11-16.
3 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
4 PMA and doxorubicin decrease viability, MTT activity and expression of CD10 marker on NALM-1 leukemic cells. Immunopharmacol Immunotoxicol. 2006;28(3):411-20.
5 Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: a mechanistic insight. Phytomedicine. 2016 Mar 15;23(3):233-42.
6 Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
7 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. Anticancer Drugs. 2008 Mar;19(3):257-65.
8 Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
9 Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes from young and elderly adults. Am J Pathol. 1993 Jul;143(1):312-20.
10 Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells. Chem Biol Interact. 2008 Oct 22;176(1):9-18.
11 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
12 Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
13 N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance. Eur J Clin Invest. 2004 Oct;34(10):683-9.
14 Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1. Biochem Biophys Res Commun. 2003 Nov 28;311(4):815-21.
15 Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res. 2005 Jan 15;65(2):516-25.
16 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
17 Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene. 2005 Jul 14;24(30):4765-77.

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