Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00311)
Xenobiotics Name
Nicardipine hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=41114"></iframe>
3D MOL 2D MOL
PubChem CID
41114
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [2]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 13.3 microM [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 0.56 microM [1]
Cytochrome P450 2C8 (CYP2C8) DME Info IC50 = 1.56 microM [2]
Cytochrome P450 2C9 (CYP2C9) DME Info IC50 = 0.378 microM [2]
Cytochrome P450 2D6 (CYP2D6) DME Info IC50 = 1.59 microM [2]
Cytochrome P450 2J2 (CYP2J2) DME Info IC50 = 1.69 microM [1]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.38 microM [1]
References
1 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.
2 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51.
3 Effects of polar oil related hydrocarbons on steroidogenesis in vitro in H295R cells. Chemosphere. 2013 Jun;92(1):106-15.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.