General Information of Xenobiotics (ID: XEO01050)
Xenobiotics Name
Dicrotophos
Xenobiotics Type
Fungicide(s), Herbicide(s) or Insecticide(s)
Classification
Pesticide/Insecticide
Structure
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3D MOL 2D MOL
PubChem CID
5371560
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1], [2]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [3]
Alcohol dehydrogenase class-III (ADH5) DME Info Homo sapiens [3]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [3]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [3]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [3]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [3]
Asparagine synthetase (ASNS) DME Info Homo sapiens [3]
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [3]
Choline/ethanolaminephosphotransferase 1 (CEPT1) DME Info Homo sapiens [3]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [3]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [3]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [3]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [3]
Galactose kinase (GALK1) DME Info Homo sapiens [3]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [3]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [3]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [3]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [3]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [3]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [3]
Methionine adenosyltransferase II beta (MAT2B) DME Info Homo sapiens [3]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [3]
Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME Info Homo sapiens [3]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [3]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [3]
Serum paraoxonase/lactonase 3 (PON3) DME Info Homo sapiens [3]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [3]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [3]
Steroid 5-alpha-reductase 3 (SRD5A3) DME Info Homo sapiens [3]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [3]
Transglutaminase K (TGM1) DME Info Homo sapiens [3]
Thiopurine methyltransferase (TPMT) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2A3 (UGT2A3) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [3]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [3]
Arylsulfatase B (ARSB) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [3]
RNA cytidine acetyltransferase (hALP) DME Info Homo sapiens [3]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [3]
Pyridoxamine-phosphate oxidase (PNPO) DME Info Homo sapiens [3]
References
1 Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503.
2 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. Toxicol In Vitro. 2019 Apr;56:93-100.
3 Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.

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