Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01367)
Xenobiotics Name
Linoleic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5280450
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [2]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [3], [4]
DME(s) Induced by This Xenobiotics
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [5]
Catalase (CAT) DME Info Homo sapiens [6]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [7]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [8]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [7]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [9]
References
1 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
2 High-fat feeding reduces endothelium-dependent vasodilation in rats: differential mechanisms for saturated and unsaturated fatty acids? Clin Exp Pharmacol Physiol. 2006 Aug;33(8):708-13.
3 Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. J Lipid Res. 2004 Dec;45(12):2211-20.
4 Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. Biochem J. 2003 Oct 15;375(Pt 2):275-85.
5 Butyrylcholinesterase expression is regulated by fatty acids in HepG2 cells. Chem Biol Interact. 2016 Nov 25;259(Pt B):276-281.
6 Lipid peroxides induce expression of catalase in cultured vascular cells. J Lipid Res. 2000 Aug;41(8):1205-13.
7 High fat diet-induced hepatic 18-carbon fatty acids accumulation up-regulates CYP2A5/CYP2A6 via NF-E2-related factor 2. Front Pharmacol. 2017 May 15;8:233.
8 Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. Br J Dermatol. 2011 Aug;165(2):269-76.
9 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress. Toxicol Appl Pharmacol. 2016 Apr 1;296:1-9.

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