Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01407)
Xenobiotics Name
Ochratoxin A
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
442530
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [4]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [7]
Catalase (CAT) DME Info Homo sapiens [8]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [9]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [10], [11]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [8]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [8]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [8]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [12], [13]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [14]
Metallothionein-1A (MT1A) DME Info Homo sapiens [8]
NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DME Info Homo sapiens [15]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [8]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [8]
References
1 An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):135-42.
2 Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):129-40.
3 Organosulfur compounds alone or in combination with vitamin C protect towards N-nitrosopiperidine- and N-nitrosodibutylamine-induced oxidative DNA damage in HepG2 cells. Chem Biol Interact. 2008 May 9;173(1):9-18.
4 Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44.
5 Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3. Chem Biol Interact. 2019 Apr 1;302:101-107.
6 Concentration-dependent binding of chlorpyrifos oxon to acetylcholinesterase. Toxicol Sci. 2007 Nov;100(1):128-35.
7 Gene expression analysis of human endometrial endothelial cells exposed to op'-DDT. Mol Hum Reprod. 2008 Feb;14(2):97-106.
8 Ezrin inhibition up-regulates stress response gene expression. J Biol Chem. 2016 Jun 17;291(25):13257-70.
9 A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
10 Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells. Drug Metab Dispos. 2004 Dec;32(12):1392-401.
11 Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Mol Pharmacol. 2002 Jan;61(1):13-9.
12 Transcriptional induction of CYP3A4 by o,p'-DDT in HepG2 cells. Toxicol Lett. 2005 May 16;157(1):41-7.
13 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.
14 The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. Toxicol Lett. 2010 Oct 20;198(3):331-41.
15 Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane. Drug Metab Dispos. 2007 Jan;35(1):95-102.

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