Detail Information of Xenobiotics
| General Information of Xenobiotics (ID: XEO04221) | ||||||
|---|---|---|---|---|---|---|
| Xenobiotics Name |
P18 analog N-5
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| Xenobiotics Type |
Amino Acid(s), Peptide(s) or Protein(s)
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| Classification |
Peptide
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| DME(s) Modulated by This Xenobiotics | ||||||
| DME(s) Inhibited by This Xenobiotics | ||||||
| Azoreductase (azoR) | DME Info | Escherichia coli | [1] | |||
| L,D-carboxypeptidase A (ldcA) | DME Info | Escherichia coli | [1] | |||
| Beta-lactamase (blaB) | DME Info | Escherichia coli | [1] | |||
| Chloramphenicolase (chlR) | DME Info | Escherichia coli | [1] | |||
| Glycoside hydrolase (cscA) | DME Info | Escherichia coli | [1] | |||
| NADPH-dependent curcumin reductase (curA) | DME Info | Escherichia coli | [1] | |||
| Cytochrome P450 102A1 (cyp102) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 MEG (cyp106) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 21A2 (cyp21) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 BM3 (cypBM3) | DME Info | Bacillus megaterium | [1] | |||
| Unclear metabolic mechanism (DME-unclear) | DME Info | Escherichia coli | [1] | |||
| Glutamate decarboxylase (gadB) | DME Info | Escherichia coli | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | Escherichia coli | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | Pseudomonas aeruginosa | [1] | |||
| Molybdopterin-dependent enzyme (molD) | DME Info | Escherichia coli | [1] | |||
| Glutamate racemase (MurI) | DME Info | Escherichia coli | [1] | |||
| Arylamine N-acetyltransferase (NAT) | DME Info | Pseudomonas aeruginosa | [1] | |||
| N-ethylmaleimide reductase (nemA) | DME Info | Escherichia coli | [1] | |||
| NADPH-dependent oxidoreductase (nfrA) | DME Info | Staphylococcus aureus | [1] | |||
| NADPH-dependent nitroreductase (nfrA1) | DME Info | Bacillus subtilis | [1] | |||
| Oxygen-insensitive NADPH nitroreductase A (nfsA) | DME Info | Escherichia coli | [1] | |||
| Oxygen-insensitive NADPH nitroreductase B (nfsB) | DME Info | Escherichia coli | [1] | |||
| NADH dehydrogenase (nuoE) | DME Info | Streptomyces griseus | [1] | |||
| Hydroxybenzoate 3-monooxygenase (pobA) | DME Info | Pseudomonas aeruginosa | [1] | |||
| Glutamate racemase (MurI) | DME Info | Bacillus subtilis | [1] | |||
| Tyramine oxidase (tynA) | DME Info | Escherichia coli | [1] | |||
| Beta-glucuronidase (uidA) | DME Info | Escherichia coli | [1] | |||
| Glutamate racemase (MurI) | DME Info | Bacillus pumilus | [1] | |||
| General stress protein 14 (ywrO) | DME Info | Bacillus subtilis | [1] | |||
| Xenobiotics-DME Activity Data | ||||||
| Xenobiotics-DME Activity Data | Azoreductase (azoR) | DME Info | MIC = 12.5 microM | [1] | ||
| L,D-carboxypeptidase A (ldcA) | DME Info | MIC = 12.5 microM | [1] | |||
| Beta-lactamase (blaB) | DME Info | MIC = 12.5 microM | [1] | |||
| Chloramphenicolase (chlR) | DME Info | MIC = 12.5 microM | [1] | |||
| Glycoside hydrolase (cscA) | DME Info | MIC = 12.5 microM | [1] | |||
| NADPH-dependent curcumin reductase (curA) | DME Info | MIC = 12.5 microM | [1] | |||
| Cytochrome P450 102A1 (cyp102) | DME Info | MIC = 1.56 microM | [1] | |||
| Cytochrome P450 MEG (cyp106) | DME Info | MIC = 1.56 microM | [1] | |||
| Cytochrome P450 21A2 (cyp21) | DME Info | MIC = 1.56 microM | [1] | |||
| Cytochrome P450 BM3 (cypBM3) | DME Info | MIC = 1.56 microM | [1] | |||
| Unclear metabolic mechanism (DME-unclear) | DME Info | MIC = 12.5 microM | [1] | |||
| Glutamate decarboxylase (gadB) | DME Info | MIC = 12.5 microM | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | MIC = 12.5 microM | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | MIC = 3.125 microM | [1] | |||
| Molybdopterin-dependent enzyme (molD) | DME Info | MIC = 12.5 microM | [1] | |||
| Glutamate racemase (MurI) | DME Info | MIC = 12.5 microM | [1] | |||
| Arylamine N-acetyltransferase (NAT) | DME Info | MIC = 3.125 microM | [1] | |||
| N-ethylmaleimide reductase (nemA) | DME Info | MIC = 12.5 microM | [1] | |||
| NADPH-dependent oxidoreductase (nfrA) | DME Info | MIC = 3.125 microM | [1] | |||
| NADPH-dependent nitroreductase (nfrA1) | DME Info | MIC = 0.78 microM | [1] | |||
| Oxygen-insensitive NADPH nitroreductase A (nfsA) | DME Info | MIC = 12.5 microM | [1] | |||
| Oxygen-insensitive NADPH nitroreductase B (nfsB) | DME Info | MIC = 12.5 microM | [1] | |||
| NADH dehydrogenase (nuoE) | DME Info | MIC = 12.5 microM | [1] | |||
| Hydroxybenzoate 3-monooxygenase (pobA) | DME Info | MIC = 3.125 microM | [1] | |||
| Glutamate racemase (MurI) | DME Info | MIC = 0.78 microM | [1] | |||
| Tyramine oxidase (tynA) | DME Info | MIC = 12.5 microM | [1] | |||
| Beta-glucuronidase (uidA) | DME Info | MIC = 12.5 microM | [1] | |||
| Glutamate racemase (MurI) | DME Info | MIC = 0.78 microM | [1] | |||
| General stress protein 14 (ywrO) | DME Info | MIC = 0.78 microM | [1] | |||
| References | ||||||
| 1 | Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. | |||||
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