Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000507)
DM Name	N-Desmethylterbinafine dihydrodiol derivative (1)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 1A2 (CYP1A2)	DME0003	N-Desmethylterbinafine	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	N-Desmethylterbinafine	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	N-Desmethylterbinafine	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Terbinafine dihydrodiol derivative (1)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Terbinafine hydrochloride		DR1557	Approved		Pityriasis versicolor

References
1	Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.

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