General Information of Drug Metabolite (DM) (ID: DM000511)
DM Name
Terbinafine dihydrodiol derivative (1)
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
Cytochrome P450 2B6 (CYP2B6) DME0020 Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Cytochrome P450 2B6 (CYP2B6) DME0020 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - N-Demethylation Terbinafine hydrochloride [1]
Full List of Drug(s) That Produce This DM By Metabolism
Terbinafine hydrochloride DR1557 Approved Pityriasis versicolor
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.

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