Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004649)
DM Name	M1 metabolite, timolol

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Timolol maleate	Oxidation - Hydrolyzationn	Timolol maleate	[1] , [2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Timolol maleate	Oxidation - Hydrolyzationn	Timolol maleate	[1] , [2]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Timolol maleate	Oxidation - Hydrolyzationn	Timolol maleate	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Timolol maleate	Oxidation - Hydrolyzationn	Timolol maleate	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Timolol maleate	Oxidation - Hydrolyzationn	Timolol maleate	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Timolol maleate Metabolite M4	Unclear - Unclear	Timolol maleate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Timolol maleate Metabolite M3	Unclear - Unclear	Timolol maleate	[1]


⏷ Show the Full List of DM

Full List of Drug(s) That Produce This DM By Metabolism
Timolol maleate		DR1595	Approved		Essential hypertension

References
1	Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug Metab Dispos. 2007 Jul;35(7):1135-41.
2	Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303.

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