Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1565)
Drug Name
Testosterone enanthate
Synonyms
Testanthate; Testate; Testenate; Testinon; Testoenant; Testonenant; Testosterone 17-enanthate; Testosterone enantate; Testosterone heptanoate; Testosterone heptoate; Testosterone heptylate; Testosterone oenanthate; Testostroval; testosterone enanthate; 17-Hydroxyandrost-4-en-3-one, 17-heptanoate; 315-37-7; Andro L.A. 200; Andropository; Androtardyl; Atlatest; DePatestrye; Delatest; Depo-Testro Med; Ditate; Durathate; Everone; Exten test; Malogen L.A.; Malogen L.A.200; NSC-17591; Orquisteron-E; Primotestone; Reposo TMD; Reposo-TMD
Indication Testosterone deficiency [ICD11: 5A81] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 400.6 Topological Polar Surface Area 43.4
Heavy Atom Count 29 Rotatable Bond Count 7
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
9416
ChEBI ID
CHEBI:9464
CAS Number
315-37-7
Formula
C26H40O3
Canonical SMILES
CCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI
1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1
InChIKey
VOCBWIIFXDYGNZ-IXKNJLPQSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Testosterone DM001963
6013
Hydrolysis - Hydrolysis 1 [10]
5alpha-dihydrotestosterone DM002519
10635
Unclear - Unclear 2 [11]
3-alpha-androstanediol glucuronide DM007061
44263363
Conjugation - Glucuronidation 3 [11]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR009623 Testosterone enanthate Testosterone Hydrolysis - Hydrolysis Unclear [10]
MR009624 Testosterone 5alpha-dihydrotestosterone Unclear - Unclear SRD5A1 [11]
MR009625 5alpha-dihydrotestosterone 3-alpha-Androstanediol glucuronide Conjugation - Glucuronidation Unclear [11]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2B6 (CYP2B6) DME0020 Homo sapiens
CP2B6_HUMAN
1.14.14.1
[2]
Cytochrome P450 2C8 (CYP2C8) DME0018 Homo sapiens
CP2C8_HUMAN
1.14.14.1
[3]
Cytochrome P450 2C9 (CYP2C9) DME0019 Homo sapiens
CP2C9_HUMAN
1.14.14.1
[4]
Cytochrome P450 3A5 (CYP3A5) DME0012 Homo sapiens
CP3A5_HUMAN
1.14.14.1
[5]
Cytochrome P450 3A7 (CYP3A7) DME0015 Homo sapiens
CP3A7_HUMAN
1.14.14.1
[6]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[7]
Phosphodiesterase 7B (PDE7B) DME0438 Homo sapiens
PDE7B_HUMAN
3.1.4.53
[8]
Steroid 5-alpha-reductase 1 (SRD5A1) DME0204 Homo sapiens
S5A1_HUMAN
1.3.1.22
[9]
Steroid 5-alpha-reductase 2 (SRD5A2) DME0218 Homo sapiens
S5A2_HUMAN
1.3.1.22
[9]
Steroid 5-alpha-reductase 3 (SRD5A3) DME0219 Homo sapiens
PORED_HUMAN
1.3.1.22
[9]
⏷ Show the Full List of 10  DME(s)
References
1 Testosterone Enanthate was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
3 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
4 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
5 In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44.
6 Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28.
7 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
8 PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132.
9 Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11).
10 LABEL: Testosterone enanthate
11 DrugBank(Pharmacology-Metabolism):Testosterone enanthate

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