Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001730)
Formula
CYP2C8 ...
SVG example
Heteroring Dehydrogenation
Reactant Nicardipine hydrochloride Product Dehydronicardipine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Heteroring Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001729 Nicardipine hydrochloride De-benzylated nicardipine Oxidation - N-Dealkylation Nicardipine hydrochloride [1], [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.

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