Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002017)
Formula
SVG example
Hydrolysis
Reactant 4- hydroxyphenelzine Product 4-hydroxyphenylacetic acid
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002020 Phenelzine 4- hydroxyphenelzine Oxidation - 4-Hydroxylation Phenelzine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005864 L-tyrosine p-hydroxyphenylacetate Unclear L-tyrosine [2]
MR003838 3-(4-Hydroxyphenyl) propionic acid (4-Hydroxyphenyl) acetic acid Unclear BE-14348A [3]
MR002016 Phenylacetic acid 4-hydroxyphenylacetic acid Oxidation - 4-Hydroxylation Phenelzine [1]
MR013574 5-(3',4',5'-trihydroxyphenyl)valeric acid 4'-hydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR004501 3-(4'-Hydroxyphenyl)propionic acid 4'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR004398 (2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013575 4'-hydroxyphenylacetic acid 3',4'-dihydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR013582 4'-hydroxyphenylacetic acid 3-methoxy-4'-hydroxyphenlacetic acid Unclear Epigallocatechin gallate [4]
MR013576 4'-hydroxyphenylacetic acid 4'-hydroxybenzoic acid Unclear Epigallocatechin gallate [4]
MR004502 4'-Hydroxyphenylacetic acid 4-Hydroxybenzoic acid Unclear VS-12343 [5]
MR004403 2-(4-Hydroxyphenyl)acetic acid (3,4-Dihydroxyphenyl)acetic acid Oxidation - Hydrolyzationn N-nonylphenol [6]
MR004399 2-(4-Hydroxyphenyl)acetic acid 1-(4-hydroxyphenyl)ethanone Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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References
1 Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
2 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
3 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
4 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement

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