Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002409)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Terbinafine hydrochloride Product N-Desmethylterbinafine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002410 Terbinafine hydrochloride 1-Naphthaldehyde Oxidation - Deamination Terbinafine hydrochloride [1]
MR002408 Terbinafine hydrochloride Hydroxyterbinafine Oxidation - Hydoxylation Terbinafine hydrochloride [1]
MR002411 Terbinafine hydrochloride Terbinafine dihydrodiol derivative (1) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
MR002412 Terbinafine hydrochloride Terbinafine dihydrodiol derivative (2) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002401 N-Desmethylterbinafine N-Desmethylhydroxyterbinafine Oxidation - Hydoxylation Terbinafine hydrochloride [1]
MR002403 N-Desmethylterbinafine N-Desmethylterbinafine dihydrodiol derivative (1) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
MR002402 N-Desmethylterbinafine N-Desmethylterbinafine dihydrodiol derivative (2) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.

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