General Information of This Metabolic Reaction (MR) (ID: MR006885)
Formula
SVG example
Reactant Phenylacetone Product Hippuric acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000221 Amphetamine Phenylacetone Oxidation - Oxidative Deamination Amphetamine [1]
MR009985 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Metamfetamine [2]
MR010001 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Methamphetamine hydrochloride [2]
MR006883 Alpha-hydroxy-amphetamine Phenylacetone Oxidation - Deamination Lisdexamfetamine [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [4]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [2]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [2]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010230 Isocarboxazid Hippuric acid Unclear - Unclear Isocarboxazid [5]
MR007547 Benzylamine M16 Benzylamine M1 Unclear Benzylamine [6]
MR004754 Midostaurin Metabolite P6 Midostaurin Metabolite P6B Unclear Midostaurin [7]
MR005014 4-Trifluoromethylphenol Hippuric acid Oxidation - O-dealkylation Fluoxetine hydrochloride [8]
MR000219 Benzoic acid Hippuric acid Conjugation - Glycine Conjugation Amphetamine [4]
MR006962 3-(Phenyl)propionic acid Hippuric acid Unclear CCG-208408 [9]
MR003837 Benzoic acid Hippuric acid Unclear BE-14348A [10]
MR005290 Cinnamic acid Metabolite Hippuric acid Unclear Cinnamic acid [11]
MR009199 Benzoic acid Hippuric acid Conjugation - Glycination 3,4-Dihydroxycinnamic Acid [12]
MR013577 4'-hydroxybenzoic acid Hippuric acid Unclear Epigallocatechin gallate [13]
⏷ Show the Full List of MR
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
3 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
4 DrugBank(Pharmacology-Metabolism)Amphetamine
5 DrugBank(Pharmacology-Metabolism):Isocarboxazid
6 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
7 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.
8 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride
9 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
10 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
11 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
12 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
13 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

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