Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00053)
Xenobiotics Name
Leflunomide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3899
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [1], [2]
Catalase (CAT) DME Info Homo sapiens [1]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [1], [2]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [1]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Methionine-R-sulfoxide reductase B1 (MSRB1) DME Info Homo sapiens [1]
Transglutaminase K (TGM1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [1], [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [3]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [1]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [1]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [1]
References
1 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
2 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
3 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.

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