Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00160)
Xenobiotics Name
Ritonavir
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
392622
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [4]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.016 microM [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Ki = 0.12 microM [2]
References
1 Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
2 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
3 Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. BMC Complement Altern Med. 2011 Jan 3;11:1.
4 Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. J Biol Chem. 2013 Aug 9;288(32):23161-70.
5 A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.

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