Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00546)
Xenobiotics Name
Salicylic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
338
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Enterococcus faecalis [1]
Beta-lactamase (blaB) DME Info Klebsiella variicola [1]
Beta-lactamase (blaB) DME Info Klebsiella aerogenes [1]
Metallo-beta-lactamase (blaM) DME Info Klebsiella pneumoniae [1]
Beta-lactamase (blaB) DME Info Klebsiella pneumoniae [1]
Cytidine deaminase (cdd) DME Info Escherichia coli [1]
Cytidine deaminase (cdd) DME Info Klebsiella pneumoniae [1]
Unclear metabolic mechanism (DME-unclear) DME Info Klebsiella pneumoniae [1]
Unclear metabolic mechanism (DME-unclear) DME Info Enterococcus faecalis [1]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [2]
Molybdopterin-dependent enzyme (molD) DME Info Klebsiella pneumoniae [1]
Methylthioribose kinase (mtnK) DME Info Klebsiella pneumoniae [1]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info Klebsiella pneumoniae [1]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [2]
Arylamine N-acetyltransferase (NAT) DME Info Klebsiella pneumoniae [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [2]
Tyrosine decarboxylase (tdc) DME Info Enterococcus faecalis [1]
VanA ligase (vanA) DME Info Enterococcus faecalis [1]
VanB ligase (vanB) DME Info Enterococcus faecalis [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [3]
Myeloperoxidase (MPO) DME Info Homo sapiens [4]
Metallothionein-1A (MT1A) DME Info Homo sapiens [5]
References
1 Salicylic acid prevents the adherence of bacteria and yeast to silastic catheters. J Biomed Mater Res. 1993 May;27(5):599-602.
2 Biodegradation of poly(anhydride-esters) into non-steroidal anti-inflammatory drugs and their effect on Pseudomonas aeruginosa biofilms in vitro and on the foreign-body response in vivo. Biomaterials. 2006 Oct;27(29):5039-48.
3 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
4 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
5 A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform. Toxicol In Vitro. 2019 Oct;60:347-358.

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