Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00877)
Xenobiotics Name
Bilirubin
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
5280352
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [1]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [2]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [4]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [4]
References
1 Global changes in gene regulation demonstrate that unconjugated bilirubin is able to upregulate and activate select components of the endoplasmic reticulum stress response pathway. J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):73-88.
2 Metabolism of bilirubin by human cytochrome P450 2A6. Toxicol Appl Pharmacol. 2012 May 15;261(1):50-8.
3 Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos. 2004 Sep;25(6):243-52.
4 Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology. 2004 Oct;40(4):951-60.

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