Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00899)
Xenobiotics Name
Methylcholanthrene
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Carcinogen
Structure
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3D MOL 2D MOL
PubChem CID
1674
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1], [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Metallothionein-2A (MT2A) DME Info Homo sapiens [7]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [9]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [10]
Thymidylate synthase (TYMS) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [11]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info Homo sapiens [12]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [14]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [13]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 > 10 microM [3]
References
1 Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A. 2006 Aug;69(15):1413-29.
2 Biological monitoring of combined exposure to organophosphates and pyrethroids. Toxicol Lett. 2002 Aug 5;134(1-3):119-24.
3 Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. Drug Metab Dispos. 2013 Oct;41(10):1782-6.
4 Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. Drug Metab Dispos. 2001 Sep;29(9):1229-35.
5 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
6 Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction. Food Chem Toxicol. 2019 Oct;132:110655.
7 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
8 Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. 2017 Apr;91(4):1815-1832.
9 Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. Toxicol Sci. 2010 Apr;114(2):204-16.
10 Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicol Sci. 2011 Sep;123(1):26-36.
11 Organophosphate pesticides increase the expression of alpha glutathione S-transferase in HepG2 cells. Toxicol In Vitro. 2011 Dec;25(8):2074-9.
12 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
13 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
14 Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicol In Vitro. 2010 Feb;24(1):346-56.

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