Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00117)
Xenobiotics Name
Copper sulfate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=24462"></iframe>
3D MOL 2D MOL
PubChem CID
24462
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [1]
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Acid phosphatase-like protein 1 (ACP6) DME Info Homo sapiens [1]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-III (ADH5) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [1]
Aldo-keto reductase 1A1 (AKR1A1) DME Info Homo sapiens [1]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [1]
Succinic semialdehyde reductase (AKR7A2) DME Info Homo sapiens [1]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [1]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [1]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [1]
Copper amine oxidase (AOC3) DME Info Homo sapiens [1]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [1]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [1]
Azoreductase (azoR) DME Info Escherichia coli [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [2]
Beta-lactamase (blaB) DME Info Escherichia coli [2]
Catalase (CAT) DME Info Homo sapiens [1]
Choline/ethanolaminephosphotransferase 1 (CEPT1) DME Info Homo sapiens [1]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [1]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [2]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [1]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [1]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [1]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [1]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [1]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [1]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [2]
Dehydropeptidase-I (DPEP1) DME Info Homo sapiens [1]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [1]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [1]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [2]
Galactose kinase (GALK1) DME Info Homo sapiens [1]
Glutamyl-tRNA(Gln) amidotransferase B (GATB) DME Info Homo sapiens [1]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [1]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [1]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [1]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [1]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [1]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [2]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [1]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 1 (MAT1A) DME Info Homo sapiens [1]
Methionine adenosyltransferase II beta (MAT2B) DME Info Homo sapiens [1]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [1]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [2]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Peptide methionine sulfoxide reductase (MSRA) DME Info Homo sapiens [1]
Methionine-R-sulfoxide reductase B2 (MSRB2) DME Info Homo sapiens [1]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [1]
Glutamate racemase (MurI) DME Info Escherichia coli [2]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [1]
Alpha-N-acetylglucosaminidase (NAG) DME Info Homo sapiens [1]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [2]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [1]
Deoxy-5'-nucleotidase 1 (NT5C) DME Info Homo sapiens [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [2]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [1]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [1]
Beta-lactamase (blaB) DME Info Burkholderia cepacia [2]
PenA beta-lactamase (penA1) DME Info Burkholderia cepacia [2]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [2]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [1]
Xylosyl phosphatase (PXYLP1) DME Info Homo sapiens [1]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [1]
Steroid 5-alpha-reductase 3 (SRD5A3) DME Info Homo sapiens [1]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
Thymidylate synthase (TYMS) DME Info Homo sapiens [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [2]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [1]
Beta-glucuronidase (uidA) DME Info Escherichia coli [2]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [1]
Uracil phosphoribosyltransferase (UPRT) DME Info Homo sapiens [1]
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Farnesol dehydrogenase (AKR1B15) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [1]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [1]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [1]
Serine sulfhydrase (CBS) DME Info Homo sapiens [1]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1], [4]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [1]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [1]
Glutathione reductase (GSR) DME Info Homo sapiens [1]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
Metallothionein-1A (MT1A) DME Info Homo sapiens [5]
Metallothionein-2A (MT2A) DME Info Homo sapiens [6]
Phosphorylcholine transferase A (PCYT1A) DME Info Homo sapiens [1]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [1]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [1]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [1]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
1 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
2 Inhibition of bacterial biofilms by carboxymethyl chitosan combined with silver, zinc and copper salts. Int J Biol Macromol. 2017 Dec;105(Pt 1):385-392.
3 Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem. 2005 Nov;279(1-2):141-7.
4 Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis. 2003 Jul;169(1):71-6.
5 Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
6 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.