Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0003)
DME Name Cytochrome P450 1A2 (CYP1A2), Homo sapiens DME Info
UniProt ID
CP1A2_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium adolescentis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium adolescentis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium angulatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Oxtriphylline Click to Show/Hide the Detail
                                 Drug ID DR1217   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium angulatum co-metabolize the drug Oxtriphylline, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium breve co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium breve co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium breve co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Ranitidine Click to Show/Hide the Detail
                                 Drug ID DR1393   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium breve co-metabolize the drug Ranitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium breve co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium longum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Bifidobacterium longum further metabolizes its metabolite (3-(3'-hydroxyphenyl)propionic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Bifidobacterium longum further metabolizes its metabolite (3-(4'-hydroxyphenyl)propionic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Bifidobacterium longum further metabolizes its metabolite (Dihydrocaffeic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Bifidobacterium longum further metabolizes its metabolite (Hydroxy-4-Methoxybenzenepropanoic Acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium longum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bifidobacterium ruminatum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Loxapine succinate Click to Show/Hide the Detail
                                 Drug ID DR0989   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Collinsella aerofaciens co-metabolize the drug Loxapine succinate, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Collinsella intestinalis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Collinsella intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Dopamine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0532   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eggerthella lenta co-metabolize the drug Dopamine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [17]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eggerthella lenta co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterorhabdus mucosicola (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug BIO-300, and Enterorhabdus mucosicola further metabolizes its metabolite (Dihydrogenistein), which can indirectly affect efficacy, safety or bioavailability of this drug. [18], [19]
                  Nocardia farcinica (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Nocardia farcinica co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [21]
                  Slackia isoflavoniconvertens (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Slackia isoflavoniconvertens co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [22]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [24], [25]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Alistipes indistinctus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Alistipes indistinctus co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Alistipes indistinctus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Alistipes indistinctus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Alistipes indistinctus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              NAB-365 Click to Show/Hide the Detail
                                 Drug ID DR0338   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides caccae co-metabolize the drug NAB-365, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides caccae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides caccae co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides caccae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides cellulosilyticus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides cellulosilyticus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides cellulosilyticus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      10 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Ergotamine tartrate Click to Show/Hide the Detail
                                 Drug ID DR0600   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Ergotamine tartrate, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Olanzapine Click to Show/Hide the Detail
                                 Drug ID DR1186   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Olanzapine, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides coprophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [23], [37]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides dorei co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides eggerthii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides finegoldii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides finegoldii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:      19 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Ergotamine tartrate Click to Show/Hide the Detail
                                 Drug ID DR0600   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Ergotamine tartrate, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Lofexidine Click to Show/Hide the Detail
                                 Drug ID DR0967   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Lofexidine, which can collectively affect efficacy, safety or bioavailability of this drug. [39], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Olanzapine Click to Show/Hide the Detail
                                 Drug ID DR1186   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Olanzapine, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Ranitidine Click to Show/Hide the Detail
                                 Drug ID DR1393   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Ranitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides fragilis co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [41], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides intestinalis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides intestinalis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      10 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides ovatus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug BIO-300, and Bacteroides sartorii further metabolizes its metabolite (Dihydrogenistein), which can indirectly affect efficacy, safety or bioavailability of this drug. [18], [42]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides sartorii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        8 Drugs Metabolized
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides stercoris co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:      13 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Ergotamine tartrate Click to Show/Hide the Detail
                                 Drug ID DR0600   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Ergotamine tartrate, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides thetaiotaomicron co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Ergotamine tartrate Click to Show/Hide the Detail
                                 Drug ID DR0600   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides uniformis co-metabolize the drug Ergotamine tartrate, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides uniformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides uniformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides uniformis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [43], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Verapamil hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1681   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Verapamil hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [44], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides vulgatus co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [41], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:      12 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides xylanisolvens co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      13 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Clonidine Click to Show/Hide the Detail
                                 Drug ID DR0352   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Clonidine, which can collectively affect efficacy, safety or bioavailability of this drug. [30], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Olanzapine Click to Show/Hide the Detail
                                 Drug ID DR1186   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Olanzapine, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Odoribacter splanchnicus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Griseofulvin Click to Show/Hide the Detail
                                 Drug ID DR0791   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Griseofulvin, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides distasonis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [45], [46]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ranitidine Click to Show/Hide the Detail
                                 Drug ID DR1393   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Ranitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides johnsonii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides merdae co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides merdae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides merdae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides merdae co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Parabacteroides merdae co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                  Prevotella buccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella buccae co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [45], [47], [48]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Prevotella copri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Tannerella forsythia (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Tannerella forsythia co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [42]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerobutyricum hallii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerobutyricum hallii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerobutyricum hallii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerococcus hydrogenalis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerococcus hydrogenalis co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerococcus hydrogenalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerostipes hadrus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [43], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerostipes hadrus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerotruncus colihominis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Pimozide Click to Show/Hide the Detail
                                 Drug ID DR1291   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerotruncus colihominis co-metabolize the drug Pimozide, which can collectively affect efficacy, safety or bioavailability of this drug. [49], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Anaerotruncus colihominis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [50], [51]
                              Chlorzoxazone Click to Show/Hide the Detail
                                 Drug ID DR0312   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacillus megaterium co-metabolize the drug Chlorzoxazone, which can collectively affect efficacy, safety or bioavailability of this drug. [52], [53], [51]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [54]
                              Nifedipine Click to Show/Hide the Detail
                                 Drug ID DR1152   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacillus megaterium co-metabolize the drug Nifedipine, which can collectively affect efficacy, safety or bioavailability of this drug. [55], [53], [51]
                              Propranolol hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1367   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacillus megaterium co-metabolize the drug Propranolol hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [56], [57]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides pectinophilus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides pectinophilus co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides pectinophilus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides pectinophilus co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Bacteroides pectinophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Cyclobenzaprine Click to Show/Hide the Detail
                                 Drug ID DR0390   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Cyclobenzaprine, which can collectively affect efficacy, safety or bioavailability of this drug. [58], [2]
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ramelteon Click to Show/Hide the Detail
                                 Drug ID DR1391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Ramelteon, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Thiothixene Click to Show/Hide the Detail
                                 Drug ID DR1584   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia hansenii co-metabolize the drug Thiothixene, which can collectively affect efficacy, safety or bioavailability of this drug. [59], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia luti co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Blautia luti co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [50], [60]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridioides difficile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridioides difficile co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridioides difficile co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:      16 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Cyclobenzaprine Click to Show/Hide the Detail
                                 Drug ID DR0390   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Cyclobenzaprine, which can collectively affect efficacy, safety or bioavailability of this drug. [58], [2]
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Fluvoxamine maleate Click to Show/Hide the Detail
                                 Drug ID DR0740   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Fluvoxamine maleate, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Paroxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1245   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Paroxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [61], [2]
                              Pimozide Click to Show/Hide the Detail
                                 Drug ID DR1291   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Pimozide, which can collectively affect efficacy, safety or bioavailability of this drug. [49], [2]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Thiothixene Click to Show/Hide the Detail
                                 Drug ID DR1584   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium botulinum co-metabolize the drug Thiothixene, which can collectively affect efficacy, safety or bioavailability of this drug. [59], [2]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium scindens co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium scindens co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium spiroforme co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium spiroforme co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium spiroforme co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium sporogenes co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium sporogenes co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium sporogenes co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium sporogenes co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium sporogenes co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium symbiosum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium symbiosum co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Clostridium symbiosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Coprococcus comes co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Coprococcus comes co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Dorea formicigenerans co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Dorea formicigenerans co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Dorea formicigenerans co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster asparagiformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster asparagiformis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Pimozide Click to Show/Hide the Detail
                                 Drug ID DR1291   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Pimozide, which can collectively affect efficacy, safety or bioavailability of this drug. [49], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterocloster bolteae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [50], [60]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterococcus faecalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterococcus faecalis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ranitidine Click to Show/Hide the Detail
                                 Drug ID DR1393   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterococcus faecalis co-metabolize the drug Ranitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Erysipelatoclostridium ramosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Erysipelatoclostridium ramosum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Erysipelatoclostridium ramosum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Eubacterium ramulus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium ramulus co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [62]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium rectale co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium rectale co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium ventriosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium ventriosum co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Eubacterium ventriosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [23], [37]
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [63], [64]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Anagrelide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0112   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Holdemanella biformis co-metabolize the drug Anagrelide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Holdemanella biformis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Holdemanella biformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Holdemanella biformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Holdemanella biformis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Hungatella hathewayi co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Hungatella hathewayi co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Ranitidine Click to Show/Hide the Detail
                                 Drug ID DR1393   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Hungatella hathewayi co-metabolize the drug Ranitidine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Hungatella hathewayi co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Lactobacillus acetotolerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Oxtriphylline Click to Show/Hide the Detail
                                 Drug ID DR1217   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus acetotolerans co-metabolize the drug Oxtriphylline, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tegafur Click to Show/Hide the Detail
                                 Drug ID DR1539   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus johnsonii co-metabolize the drug Tegafur, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [65]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus reuteri co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus reuteri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus reuteri co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus reuteri co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [23], [37]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Lactobacillus rhamnosus further metabolizes its metabolite (3-(3'-hydroxyphenyl)propionic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Lactobacillus rhamnosus further metabolizes its metabolite (3-(4'-hydroxyphenyl)propionic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Lactobacillus rhamnosus further metabolizes its metabolite (Dihydrocaffeic acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                              Hesperetin Click to Show/Hide the Detail
                                 Drug ID DR0808   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Hesperetin, and Lactobacillus rhamnosus further metabolizes its metabolite (Hydroxy-4-Methoxybenzenepropanoic Acid), which can indirectly affect efficacy, safety or bioavailability of this drug. [9], [10]
                  Lactobacillus sakei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Erythromycin stearate Click to Show/Hide the Detail
                                 Drug ID DR0614   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Lactobacillus sakei co-metabolize the drug Erythromycin stearate, which can collectively affect efficacy, safety or bioavailability of this drug. [66], [67], [68]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Marvinbryantia formatexigens co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Roseburia intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [23], [37]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus gnavus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus gnavus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus gnavus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus gnavus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus lactaris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus lactaris co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus lactaris co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus lactaris co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus torques co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Ruminococcus torques co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Subdoligranulum variabile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Idebenone Click to Show/Hide the Detail
                                 Drug ID DR0853   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Subdoligranulum variabile co-metabolize the drug Idebenone, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Subdoligranulum variabile co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Subdoligranulum variabile co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Victivallis vadensis co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Proteobacteria
                  Acinetobacter baumannii (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pyrazinamide Click to Show/Hide the Detail
                                 Drug ID DR1372   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Acinetobacter baumannii co-metabolize the drug Pyrazinamide, which can collectively affect efficacy, safety or bioavailability of this drug. [69], [70]
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [50], [60]
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Edwardsiella tarda co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Edwardsiella tarda co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterobacter cancerogenus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterobacter cancerogenus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterobacter cancerogenus co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Enterobacter cancerogenus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [50], [60]
                              Conjugated estrogens Click to Show/Hide the Detail
                                 Drug ID DR0377   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Conjugated estrogens, which can collectively affect efficacy, safety or bioavailability of this drug. [71], [72]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Flunitrazepam Click to Show/Hide the Detail
                                 Drug ID DR0712   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Flunitrazepam, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [73]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Primaquine Click to Show/Hide the Detail
                                 Drug ID DR1339   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug Primaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              SRT-501 Click to Show/Hide the Detail
                                 Drug ID DR1406   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Escherichia coli co-metabolize the drug SRT-501, which can collectively affect efficacy, safety or bioavailability of this drug. [74], [75]
                  Neisseria sicca (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ethanol Click to Show/Hide the Detail
                                 Drug ID DR0655   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Neisseria sicca co-metabolize the drug Ethanol, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [76]
                  Novosphingobium aromaticivorans (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Conjugated estrogens Click to Show/Hide the Detail
                                 Drug ID DR0377   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Novosphingobium aromaticivorans co-metabolize the drug Conjugated estrogens, which can collectively affect efficacy, safety or bioavailability of this drug. [71], [77]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Proteus penneri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Proteus penneri co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Proteus penneri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Providencia alcalifaciens co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Providencia rettgeri co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Providencia stuartii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Providencia stuartii co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Providencia stuartii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [78], [79]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Salmonella enterica co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [63], [80], [81]
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Salmonella enterica co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Pantoprazole sodium Click to Show/Hide the Detail
                                 Drug ID DR1236   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Akkermansia muciniphila co-metabolize the drug Pantoprazole sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Pimozide Click to Show/Hide the Detail
                                 Drug ID DR1291   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Akkermansia muciniphila co-metabolize the drug Pimozide, which can collectively affect efficacy, safety or bioavailability of this drug. [49], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Akkermansia muciniphila co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [50], [60]
      Archaea: Euryarchaeota
                  Methanobrevibacter oralis (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Methanobrevibacter oralis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [82]
                  Methanobrevibacter smithii (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Methanobrevibacter smithii co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [82]
                  Methanomassiliicoccus luminyensis (thermoplasmata) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Methanomassiliicoccus luminyensis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [82]
                  Methanosphaera stadtmanae (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A2 (CYP1A2) and Methanosphaera stadtmanae co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [82]
References
1 Clinically significant psychotropic drug-drug interactions in the primary care setting. Curr Psychiatry Rep. 2012 Aug;14(4):376-90.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
4 PharmGKB summary: very important pharmacogene information for CYP1A2. Pharmacogenet Genomics. 2012 Jan;22(1):73-7.
5 Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio. 2016 Apr 5;7(2):e02210-15.
6 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
7 Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists. Clin Pharmacol Ther. 1999 Apr;65(4):369-76.
8 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.
9 In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol. 2002 May;40(5):609-16.
10 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
11 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
12 Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide. Clin Pharmacokinet. 2007;46(7):613-22.
13 Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Drug Metab Dispos. 2010 Aug;38(8):1381-91.
14 Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3.
15 In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407.
16 Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Pharmacogenetics. 1998 Jun;8(3):251-8.
17 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
18 Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein. J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):230-4.
19 Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Appl Environ Microbiol. 2008 Aug;74(15):4847-52.
20 Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31.
21 Mechanism of rifampicin inactivation in Nocardia farcinica. PLoS One. 2016 Oct 5;11(10):e0162578.
22 Daidzein and genistein are converted to equol and 5-hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats. J Nutr. 2012 Jan;142(1):40-6.
23 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
24 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
25 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
26 Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44.
27 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.
28 Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50.
29 Pharmacokinetic interactions study between carvedilol and some antidepressants in rat liver microsomes - a comparative study. Med Pharm Rep. 2019 Apr;92(2):158-164.
30 CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.
31 Clinical pharmacokinetics and pharmacodynamics of clopidogrel. Clin Pharmacokinet. 2015 Feb;54(2):147-66.
32 Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94.
33 Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73.
34 Interactions between the cytochrome P450 system and the second-generation antipsychotics. J Psychiatry Neurosci. 2003 Mar;28(2):99-112.
35 In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805.
36 Open-label, dose-titration and continuation study to assess efficacy, safety, and pharmacokinetics of anagrelide in treatment-nae Japanese patients with essential thrombocythemia. Int J Hematol. 2013 Mar;97(3):360-8.
37 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
38 Kinetic mechanism of the activation of human plasminogen by streptokinase. Biochemistry. 1975 Oct 7;14(20):4459-65.
39 The Drugs.com International Drug Name Database: Lofexidine
40 Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8.
41 Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 1;6(3):157-64.
42 Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. J Nutr. 2011 Jun;141(6):1120-6.
43 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
44 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
45 Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):551-8.
46 Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.
47 Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946-2956.
48 Regulating gut flora dysbiosis in obese mice by electroacupuncture. Am J Chin Med. 2018 Oct 4:1-17.
49 Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. J Pharmacol Exp Ther. 1998 May;285(2):428-37.
50 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
51 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
52 Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. Pharmacogenetics. 1998 Oct;8(5):375-82.
53 Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23.
54 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
55 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
56 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
57 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
58 Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
59 In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. Pharmacol Res Perspect. 2017 Mar 2;5(2):e00299.
60 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
61 CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. Pharmacogenomics. 2010 Nov;11(11):1535-43.
62 Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett. 2002 Mar 5;208(2):197-202.
63 Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8.
64 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
65 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
66 Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Drug Metab Dispos. 1998 Nov;26(11):1053-7.
67 Identification of Lactobacillus sakei genes induced during meat fermentation and their role in survival and growth. Appl Environ Microbiol. 2007 Apr;73(8):2522-31.
68 Degradation of various insecticides in cooked eggs during in vitro human digestion. Environ Pollut. 2018 Dec;243(Pt A):437-443.
69 The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80.
70 Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide. Angew Chem Int Ed Engl. 2009;48(48):9176-9.
71 Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women. J Clin Pharmacol. 2006 Nov;46(11):1299-307.
72 Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
73 Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9.
74 Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82.
75 Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
76 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
77 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
78 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
79 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
80 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
81 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
82 The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J Antimicrob Chemother. 2011 Sep;66(9):2038-44.

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