Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0018)
DME Name Cytochrome P450 2C8 (CYP2C8), Homo sapiens DME Info
UniProt ID
CP2C8_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium adolescentis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium adolescentis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium adolescentis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium breve co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium breve co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium breve co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium breve co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium longum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium longum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium longum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium ruminatum co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium ruminatum co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium ruminatum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bifidobacterium ruminatum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pitavastatin calcium Click to Show/Hide the Detail
                                 Drug ID DR1306   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Collinsella aerofaciens co-metabolize the drug Pitavastatin calcium, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Collinsella aerofaciens co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Collinsella intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Collinsella intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Collinsella intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eggerthella lenta co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [13], [14]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Streptomyces avermitilis co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [16], [13]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Alistipes indistinctus co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Alistipes indistinctus co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Alistipes indistinctus co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Alistipes indistinctus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Alistipes indistinctus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides caccae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides cellulosilyticus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides cellulosilyticus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides cellulosilyticus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides coprophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:      12 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [12], [21]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides dorei co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides eggerthii co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides eggerthii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides eggerthii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides finegoldii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides fragilis co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides intestinalis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides oleiciplenus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides oleiciplenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [25]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides ovatus co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides ovatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides ovatus co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides ovatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:      13 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides sartorii co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides stercoris co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides stercoris co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides stercoris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:      10 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides thetaiotaomicron co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Cefaloridine Click to Show/Hide the Detail
                                 Drug ID DR0285   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides uniformis co-metabolize the drug Cefaloridine, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [27]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides uniformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides uniformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides uniformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      14 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Verapamil hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1681   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Verapamil hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides vulgatus co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:      13 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides xylanisolvens co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      11 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Repaglinide Click to Show/Hide the Detail
                                 Drug ID DR1404   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Repaglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [23], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Odoribacter splanchnicus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides distasonis co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        8 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides johnsonii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides merdae co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides merdae co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides merdae co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides merdae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Parabacteroides merdae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Prevotella copri co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Prevotella copri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naloxone Click to Show/Hide the Detail
                                 Drug ID DR1127   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Prevotella copri co-metabolize the drug Naloxone, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Prevotella copri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Prevotella copri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerobutyricum hallii co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerobutyricum hallii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerobutyricum hallii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerobutyricum hallii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerococcus hydrogenalis co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerococcus hydrogenalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerococcus hydrogenalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerococcus hydrogenalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerococcus hydrogenalis co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerostipes hadrus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerostipes hadrus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerostipes hadrus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerotruncus colihominis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Anaerotruncus colihominis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Amodiaquine Click to Show/Hide the Detail
                                 Drug ID DR0102   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacillus megaterium co-metabolize the drug Amodiaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [30]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [31]
                              Mefenamic acid Click to Show/Hide the Detail
                                 Drug ID DR1014   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacillus megaterium co-metabolize the drug Mefenamic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [31]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacillus megaterium co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [15], [32], [33]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides pectinophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides pectinophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Bacteroides pectinophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        8 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia hansenii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia luti co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Blautia luti co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridioides difficile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridioides difficile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium botulinum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium perfringens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium scindens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium scindens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium scindens co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium spiroforme co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium spiroforme co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium spiroforme co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Celecoxib Click to Show/Hide the Detail
                                 Drug ID DR0286   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium sporogenes co-metabolize the drug Celecoxib, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium sporogenes co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium sporogenes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium symbiosum co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium symbiosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Clostridium symbiosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Coprococcus comes co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Coprococcus comes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Coprococcus comes co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Dorea formicigenerans co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Dorea formicigenerans co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Dorea formicigenerans co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster asparagiformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster asparagiformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster asparagiformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster bolteae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster bolteae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterocloster bolteae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterococcus faecalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterococcus faecalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Erysipelatoclostridium ramosum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Erysipelatoclostridium ramosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Eubacterium limosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium limosum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium rectale co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium rectale co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium rectale co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium ventriosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Eubacterium ventriosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [12], [21]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Celecoxib Click to Show/Hide the Detail
                                 Drug ID DR0286   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Celecoxib, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Holdemanella biformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Hungatella hathewayi co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Hungatella hathewayi co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Hungatella hathewayi co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tegafur Click to Show/Hide the Detail
                                 Drug ID DR1539   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Lactobacillus johnsonii co-metabolize the drug Tegafur, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [37]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Lactobacillus reuteri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Lactobacillus reuteri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [12], [21]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Marvinbryantia formatexigens co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Marvinbryantia formatexigens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Marvinbryantia formatexigens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Roseburia intestinalis co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Roseburia intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Roseburia intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Roseburia intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [12], [21]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus gnavus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus gnavus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Eszopiclone Click to Show/Hide the Detail
                                 Drug ID DR0652   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus lactaris co-metabolize the drug Eszopiclone, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus lactaris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus lactaris co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus torques co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Ruminococcus torques co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Subdoligranulum variabile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Subdoligranulum variabile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
      Bacteria: Fusobacteria
                  Fusobacterium varium (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Fusobacterium varium co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Victivallis vadensis co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Victivallis vadensis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Victivallis vadensis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Victivallis vadensis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
      Bacteria: Proteobacteria
                  Burkholderia multivorans (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Cefaloridine Click to Show/Hide the Detail
                                 Drug ID DR0285   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Burkholderia multivorans co-metabolize the drug Cefaloridine, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [38]
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Edwardsiella tarda co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Edwardsiella tarda co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Edwardsiella tarda co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterobacter cancerogenus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterobacter cancerogenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Enterobacter cancerogenus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [39]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Paclitaxel Click to Show/Hide the Detail
                                 Drug ID DR1227   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Paclitaxel, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Sulfinpyrazone Click to Show/Hide the Detail
                                 Drug ID DR1515   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Escherichia coli co-metabolize the drug Sulfinpyrazone, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Proteus penneri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Proteus penneri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Proteus penneri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia alcalifaciens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia alcalifaciens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Loperamide hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0974   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia rettgeri co-metabolize the drug Loperamide hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia rettgeri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia rettgeri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia stuartii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia stuartii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Providencia stuartii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [40], [41]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Salmonella enterica co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Salmonella enterica co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Shewanella oneidensis (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Shewanella oneidensis co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [43], [44]
                  Sphingomonas colocasiae (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ibuprofen Click to Show/Hide the Detail
                                 Drug ID DR0844   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug. [45], [46]
      Bacteria: Synergistetes
                  Synergistetes bacterium (synergistetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Synergistetes bacterium co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [47], [48]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Akkermansia muciniphila co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C8 (CYP2C8) and Akkermansia muciniphila co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
References
1 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
4 Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7.
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
6 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
7 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
8 Drug-drug interaction between losartan and paclitaxel in human liver microsomes with different CYP2C8 genotypes. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):493-8.
9 Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8.
10 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
11 Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12.
12 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
13 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
14 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
15 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
16 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
17 Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54.
18 Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. J Pharmacol Exp Ther. 1997 Jul;282(1):294-300.
19 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81.
20 Buprenorphine in cancer pain. Support Care Cancer. 2005 Nov;13(11):878-87.
21 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
22 Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. Br J Clin Pharmacol. 2017 Sep;83(9):1966-1975.
23 Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108.
24 Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8.
25 Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995 Apr;84(4):516-7. Letter
26 Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.
27 Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61.
28 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
29 Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug;82(2):197-203.
30 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
31 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
32 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
33 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
34 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
35 Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies. Pharmacogenomics. 2009 Sep;10(9):1489-510.
36 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
37 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
38 Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.
39 Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. Drug Metab Dispos. 1995 Mar;23(3):354-62.
40 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
41 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
42 Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol. 2007 May 1;178(9):5533-42.
43 Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
44 The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol. 2010 Mar;161(2):144-52.
45 Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87.
46 Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2. Microbiology. 2013 Mar;159(Pt 3):621-632.
47 Bacterial community changes and antibiotic resistance gene quantification in microbial electrolysis cells during long-term sulfamethoxazole treatment. Bioresour Technol. 2019 Dec;294:122170.
48 Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches. Microb Pathog. 2016 May;94:90-103.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.