Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0037)
DME Name Steroid 21-hydroxylase (CYP21A2), Homo sapiens DME Info
UniProt ID
CP21A_HUMAN
EC Number    EC: 1.14.14.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins up-regulates the expression of DME CYP21A2 [1]
                              Fipronil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01302   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fipronil up-regulates the expression of DME CYP21A2 [2]
                              Pentabromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00904   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Pentabromophenol up-regulates the expression of DME CYP21A2 [3]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              1-nitropyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00893   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 1-nitropyrene inhibits the expression of DME CYP21A2 [4]
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP21A2 [5]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME CYP21A2 [6]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3-Methylsulfonyl-dde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01100   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 3-Methylsulfonyl-dde inhibits the expression of DME CYP21A2 [7]
                              Galaxolide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00984   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Galaxolide inhibits the drug-metabolizing activity of DME CYP21A2 [8]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME CYP21A2 [9]
                              HT-2 toxin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01515   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation HT-2 toxin up-regulates the expression of DME CYP21A2 [9]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME CYP21A2 [10], [11]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP21A2 [12]
                              Ketoconazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole induces the drug-metabolizing activity of DME CYP21A2 [13]
                              Obeticholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00165   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Obeticholic acid inhibits the drug-metabolizing activity of DME CYP21A2 [14]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the expression of DME CYP21A2 [15]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the drug-metabolizing activity of DME CYP21A2 [16]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the expression of DME CYP21A2 [17]
                              Torcetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00627   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Torcetrapib up-regulates the expression of DME CYP21A2 [18]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME CYP21A2 [19]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3,3',4,5'-tetrahydroxystilbene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01133   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 3,3',4,5'-tetrahydroxystilbene inhibits the expression of DME CYP21A2 [20]
                              Tributyltin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01491   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Tributyltin inhibits the expression of DME CYP21A2 [21]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-acetyltributylcitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01612   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation 2-acetyltributylcitrate up-regulates the expression of DME CYP21A2 [19]
References
1 An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol Lett. 2015 Mar 4;233(2):84-94.
2 Impact of environmental chemicals on the transcriptome of primary human hepatocytes: potential for health effects. J Biochem Mol Toxicol. 2016 Aug;30(8):375-95.
3 Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China. Toxicol Lett. 2014 Jul 3;228(1):25-33.
4 Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells. Toxicol Lett. 2009 Jan 30;184(2):126-33.
5 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
6 Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol Lett. 2011 Aug 28;205(2):146-53.
7 Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):281-9.
8 Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells. Chemosphere. 2013 Jan;90(3):1227-35.
9 An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 2012 Nov 15;214(3):268-78.
10 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
11 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
12 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
13 A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21. J Enzyme Inhib Med Chem. 2006 Oct;21(5):547-56.
14 An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicol In Vitro. 2014 Mar;28(2):231-9.
15 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
16 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
17 Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology. 2016 Mar 28;350-352:1-14.
18 Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: a systems toxicology assessment. Food Chem Toxicol. 2018 May;115:109-126.
19 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
20 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
21 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.

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