Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1476)
DME Name Azoreductase (azoR), Streptococcus pyogenes DME Info
UniProt ID
A0A074IU04_STRSL
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Streptococcus pyogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus pyogenes
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      81 Xenobiotics
                              Actagardine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02133   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Actagardine inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [1], [2]
                              Anopheles cecropin-A amidated isoform Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02230   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Anopheles cecropin-A amidated isoform inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.1-0.25 microM) [3], [4]
                              Antibacterial protein PR-39 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02248   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial protein PR-39 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 2 microM) [5], [6]
                              Antimicrobial peptide NK-lysin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02293   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide NK-lysin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 34 microM) [7], [8]
                              Antimicrobial protein AMP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02297   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial protein AMP1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC < 50 ug/ml) [9]
                              Arachnid gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03497   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arachnid gomesin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1.6-3.15 microM) [10]
                              Bactenecin bacP3R-V Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02368   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin bacP3R-V inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 4 ug/ml) [11]
                              Bactenecin cyclic derivative BacP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02365   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin cyclic derivative BacP1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 64 ug/ml) [11]
                              Bactenecin cyclic derivative BacP3R Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02367   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin cyclic derivative BacP3R inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 8 ug/ml) [11]
                              Bactenecin cyclic derivative BacR Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02369   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin cyclic derivative BacR inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 8 ug/ml) [11]
                              Bactenecin cyclic derivative BacW Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02388   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin cyclic derivative BacW inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 2 ug/ml) [11]
                              Bactenecin cyclic derivative BacW2R Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02389   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bactenecin cyclic derivative BacW2R inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1 ug/ml) [11]
                              Cecropin-A(1-7)-melittin(1-8) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02756   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(1-8) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.7 microM) [12]
                              Cecropin-A(1-7)-melittin(2-9) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02757   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(2-9) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.5 microM) [12], [13]
                              Cecropin-A(1-7)-melittin(3-10) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02758   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(3-10) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1 microM) [12]
                              Cecropin-A(1-7)-melittin(4-11) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02759   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(4-11) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.7 microM) [12], [14]
                              Cecropin-A(1-7)-melittin(5-12) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02760   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(5-12) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.4 microM) [12]
                              Cecropin-A(1-7)-melittin(6-13) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02761   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(6-13) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.4 microM) [12]
                              Cecropin-A(1-8)-melittin(1-10) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02762   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-10) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.8 microM) [12]
                              Cecropin-A(1-8)-melittin(1-12) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02763   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-12) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.1 microM) [12]
                              Cecropin-A(1-8)-melittin(1-13) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02764   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-13) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1 microM) [12]
                              Cecropin-A(1-8)-melittin(1-18) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02765   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-18) hybrid inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 2 microM) [12]
                              Cecropin-P1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02774   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-P1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 19 microM) [15], [16]
                              CP11CN peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02932   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CP11CN peptide inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 8 ug/ml) [17]
                              Cryptdin related peptide CRS4C-1d Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02959   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cryptdin related peptide CRS4C-1d inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [18]
                              Cryptdin related peptide CRS4C-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02960   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cryptdin related peptide CRS4C-2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [18]
                              Cryptdin related peptide CRS4C-2b Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02961   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cryptdin related peptide CRS4C-2b inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [18]
                              Cryptdin related sequence CRS4C-3c Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02955   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cryptdin related sequence CRS4C-3c inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [18]
                              Eumenine mastoparan-EF Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03363   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Eumenine mastoparan-EF inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC > 30 microM) [19]
                              Eumenine mastoparan-ER Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03364   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Eumenine mastoparan-ER inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC > 30 microM) [19]
                              Eumenitin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03367   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Eumenitin F inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 30 microM) [19]
                              Eumenitin R Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03368   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Eumenitin R inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 15 microM) [19]
                              Gallinacin-13 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03462   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gallinacin-13 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [20]
                              Gallinacin-8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03467   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gallinacin-8 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [20]
                              Gramicidin S Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03503   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gramicidin S inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1.6 ug/ml) [21]
                              Gramicidin [Scr2]-GS analogue Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03501   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gramicidin [Scr2]-GS analogue inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 25 ug/ml) [21]
                              Gramicidin [Ser2,2']-GS analogue Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03502   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gramicidin [Ser2,2']-GS analogue inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 25 ug/ml) [21]
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 4 ug/ml) [22]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 4 ug/ml) [22]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 4 ug/ml) [22]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [23], [24]
                              Indolicidin derivative CP10A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02930   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Indolicidin derivative CP10A inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1 ug/ml) [17]
                              Insect attacin-C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02333   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect attacin-C inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC > 200 microM) [25]
                              Insect cecropin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02768   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect cecropin-A inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 10-25 ug/ml) [26]
                              Insect peptide C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04542   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect peptide C inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [27]
                              Invertebrate defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03099   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Invertebrate defensin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [28]
                              L-amino-acid oxidase Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03793   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L-amino-acid oxidase inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 8 microM) [29]
                              Linear bactenecin bac2S-NH2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03904   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Linear bactenecin bac2S-NH2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 2 ug/ml) [11]
                              Linear bactenecin bacS-NH2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03905   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Linear bactenecin bacS-NH2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 8 ug/ml) [11]
                              Lingual antimicrobial peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03908   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lingual antimicrobial peptide inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [30]
                              Mastoparan-L [I5,R8] derivative Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01816   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mastoparan-L [I5,R8] derivative inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 6.25 microM) [31]
                              Melittin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04057   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Melittin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.5 microM) [32]
                              Moricin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04128   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Moricin-1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.25 microM) [33], [34]
                              Neutrophil defensin HANP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [35]
                              Neutrophil defensin HANP-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04261   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [35]
                              Neutrophil defensin HANP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04265   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [35]
                              Neutrophil defensin HANP-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04268   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-4 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [35]
                              Nisin U Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04320   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin U inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [36]
                              Nosiheptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04332   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nosiheptide inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 0.00028 ug/ml) [37], [38]
                              Paneth cell-specific alpha-defensin 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04463   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Paneth cell-specific alpha-defensin 1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [39]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1.25-2.5 microM) [40]
                              Plantazolicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04624   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantazolicin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 128 ug/ml) [41]
                              Ponericin G1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04695   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin G3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04696   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin G4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04697   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G4 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin G6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04698   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G6 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-L2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04699   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-L2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04700   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04701   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04702   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W4 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04703   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W5 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Ponericin-W6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04704   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W6 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [42]
                              Rhinocerosin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04851   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rhinocerosin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1 ug/ml) [43]
                              Rugosin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04865   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rugosin-A inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 50 ug/ml) [44]
                              Rugosin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04866   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rugosin-B inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 12.5 ug/ml) [44]
                              Salivaricin 9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04900   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Salivaricin 9 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [45]
                              Spider gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03498   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spider gomesin inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1.6-3.15 microM) [10]
                              Stomoxyn Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04995   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Stomoxyn inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 1.56-3.12 microM) [46], [47]
                              Subtilosin A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05009   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subtilosin A1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 100 microM) [48]
                              Temporin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05076   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-A inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 2.0 microM) [49]
                              Temporin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05085   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-B inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes (MIC = 7.0 ug/ml) [49]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:      12 Xenobiotics
                              Actinobacterium sp culture extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02973   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Actinobacterium sp culture extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [50]
                              Bacillus firmus coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02915   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus firmus coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Bacillus horikoshii coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02916   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus horikoshii coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Bacillus pumilus coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02917   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus pumilus coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Bacillus subtilis coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02918   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus subtilis coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Halomonas salaria coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02919   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Halomonas salaria coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Micrococcus luteus culture extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02975   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Micrococcus luteus culture extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [50]
                              Propionibacterium sp culture extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02977   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Propionibacterium sp culture extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [50]
                              Streptomyces akiyoshinensis culture extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02978   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Streptomyces akiyoshinensis culture extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [50]
                              Streptomyces rochei culture extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02979   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Streptomyces rochei culture extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [50]
                              Vibrio natriegens coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02920   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Vibrio natriegens coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                              Vibrio parahaemolyticus coral bacterial extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02921   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Vibrio parahaemolyticus coral bacterial extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [51]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Limonene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01559   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Limonene inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [52]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Eleutherine americana bulb extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02652   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Eleutherine americana bulb extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [53]
                              Rhodomyrtus tomentosa leaf extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03837   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Rhodomyrtus tomentosa leaf extract inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [53]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Acetylcysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00110   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetylcysteine inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus pyogenes [54]
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