Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO02759)
Xenobiotics Name
Cecropin-A(1-7)-melittin(4-11) hybrid
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1], [2]
Azoreductase (azoR) DME Info Streptococcus pyogenes [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Escherichia coli [1], [2]
Chloramphenicolase (chlR) DME Info Escherichia coli [1], [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 MEG (cyp106) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info Bacillus megaterium [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1], [2]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1], [2]
Glutamate racemase (MurI) DME Info Escherichia coli [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1], [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1], [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [1], [2]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1], [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1], [2]
Glutamate racemase (MurI) DME Info Bacillus subtilis [1], [2]
Tyramine oxidase (tynA) DME Info Escherichia coli [1], [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1], [2]
Glutamate racemase (MurI) DME Info Bacillus pumilus [1], [2]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [1], [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Azoreductase (azoR) DME Info MIC = 0.6 microM [1], [2]
Azoreductase (azoR) DME Info MIC = 0.7 microM [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 0.6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.6 microM [1], [2]
Chloramphenicolase (chlR) DME Info MIC = 0.6 microM [1], [2]
Glycoside hydrolase (cscA) DME Info MIC = 0.6 microM [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 0.6 microM [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info MIC = 0.5 microM [1], [2]
Cytochrome P450 MEG (cyp106) DME Info MIC = 0.5 microM [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info MIC = 0.5 microM [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info MIC = 0.5 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 0.6 microM [1], [2]
Glutamate decarboxylase (gadB) DME Info MIC = 0.6 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 0.6 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 4 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 0.6 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 0.6 microM [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 4 microM [1], [2]
N-ethylmaleimide reductase (nemA) DME Info MIC = 0.6 microM [1], [2]
NADPH-dependent oxidoreductase (nfrA) DME Info MIC = 8 microM [1], [2]
NADPH-dependent nitroreductase (nfrA1) DME Info MIC = 0.6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 0.6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 0.6 microM [1], [2]
NADH dehydrogenase (nuoE) DME Info MIC = 0.6 microM [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info MIC = 4 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 0.6 microM [1], [2]
Tyramine oxidase (tynA) DME Info MIC = 0.6 microM [1], [2]
Beta-glucuronidase (uidA) DME Info MIC = 0.6 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 0.6 microM [1], [2]
General stress protein 14 (ywrO) DME Info MIC = 0.6 microM [1], [2]
References
1 Shortened cecropin A-melittin hybridsSignificant size reduction retains potent antibiotic activity. FEBS Lett. 1992 Jan 20;296(2):190-4.
2 Design, recombinant expression, and antibacterial activity of the cecropins-melittin hybrid antimicrobial peptides. Curr Microbiol. 2010 Sep;61(3):169-75.

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