Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002822)
Formula Reactant Capsaicin Product Capsaicin metabolite M5M7
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002826 Capsaicin Capsaicin glucuronide Conjugation - Glucuronidation Capsaicin [1]
MR002818 Capsaicin Capsaicin metabolite M1 Oxidation - Dehydrogenation Capsaicin [2]
MR002819 Capsaicin Capsaicin metabolite M2 Oxidation - Omega-Hydroxylation Capsaicin [2]
MR002820 Capsaicin Capsaicin metabolite M3 Oxidation - Omega-1-Hydroxylation Capsaicin [2]
MR002821 Capsaicin Capsaicin metabolite M4 Oxidation - Dehydrogenation Capsaicin [2]
MR002823 Capsaicin Capsaicin metabolite M6 Oxidation - O-Dehydrogenation Capsaicin [2]
MR002824 Capsaicin Capsaicin metabolite M8 Oxidation - N-Dehydrogenation; Oxygenation Capsaicin [2]
MR002825 Capsaicin Capsaicin metabolite M9 Oxidation - N-Dehydrogenation Capsaicin [2]
References
1 Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1325-36. doi: 10.1517/17425255.2014.954548.
2 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.

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