Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000554)
DM Name
Capsaicin metabolite M9
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 1A2 (CYP1A2) DME0003
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 2B6 (CYP2B6) DME0020
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 2C8 (CYP2C8) DME0018
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 2C9 (CYP2C9) DME0019
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 2D6 (CYP2D6) DME0009
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 2E1 (CYP2E1) DME0013
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021
Capsaicin
Oxidation - N-Dehydrogenation Capsaicin [1]
Full List of Drug(s) That Produce This DM By Metabolism
Capsaicin DR0268 Approved Herpes zoster
References
1 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.

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