Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01248)
Xenobiotics Name
Chlorpyrifos
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
2730
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [3]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [4]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5], [6]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [7]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [7]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [6]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [8]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [9], [10]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [11]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [12]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [13]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [13]
Glutathione reductase (GSR) DME Info Homo sapiens [10]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [14]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [15]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [16], [17]
References
1 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. Toxicol In Vitro. 2019 Apr;56:93-100.
2 Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
3 New tools in diagnosis and biomonitoring of intoxications with organophosphorothioates: case studies with chlorpyrifos and diazinon. Chem Biol Interact. 2013 Mar 25;203(1):96-102.
4 B-esterase determination and organophosphate insecticide inhibitory effects in JEG-3 trophoblasts. Toxicol In Vitro. 2016 Apr;32:190-7.
5 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
6 An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63.
7 The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. Toxicol In Vitro. 2013 Aug;27(5):1584-8.
8 PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells. Toxicology. 2015 Aug 6;334:72-80.
9 Chlorpyrifos induces the expression of the epstein-barr virus lytic cycle activator BZLF-1 via reactive oxygen species. Oxid Med Cell Longev. 2015;2015:309125.
10 The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells. Placenta. 2013 Sep;34(9):792-8.
11 Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET). Drug Metabol Drug Interact. 2008;23(3-4):237-60.
12 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
13 Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32.
14 Organophosphate pesticides increase the expression of alpha glutathione S-transferase in HepG2 cells. Toxicol In Vitro. 2011 Dec;25(8):2074-9.
15 APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells. Mol Cell Biochem. 2018 Apr;441(1-2):201-216.
16 JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis. Toxicol Lett. 2013 Apr 26;218(3):235-45.
17 Rosiglitazone inhibits chlorpyrifos-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):159-71.

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